{"id":744,"date":"2021-03-20T22:58:57","date_gmt":"2021-03-20T22:58:57","guid":{"rendered":"https:\/\/ladomerylab.org\/?post_type=invited_reviews&#038;p=744"},"modified":"2023-03-05T22:59:07","modified_gmt":"2023-03-05T22:59:07","slug":"srpk1-inhibition-in-vivo-modulation-of-vegf-splicing-and-potential-treatment-for-multiple-diseases","status":"publish","type":"invited_reviews","link":"https:\/\/ladomerylab.org\/invited-reviews\/srpk1-inhibition-in-vivo-modulation-of-vegf-splicing-and-potential-treatment-for-multiple-diseases\/","title":{"rendered":"SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases"},"content":{"rendered":"<p>SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains. Its substrates include a family of SR proteins that are key regulators of mRNA AS (alternative splicing). VEGF (vascular endothelial growth factor), a principal angiogenesis factor contains an alternative 3\u2019 splice site in the terminal exon that defines a family of isoforms with a different amino acid sequence at the C-terminal end, resulting in anti-angiogenic activity in the context of VEGF165-driven neovascularization. It has been shown recently in our laboratories that SRPK1 regulates the choice of this splice site through phosphorylation of the splicing factor SRSF1 (serine\/arginine-rich splicing factor 1). The present review summarizes progress that has been made to understand how SRPK1 inhibition may be used to manipulate the balance of pro- and anti-angiogenic VEGF isoforms in animal models in vivo and therefore control abnormal angiogenesis and other pathophysiological processes in multiple disease states.<\/p>\n","protected":false},"template":"","_links":{"self":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/invited_reviews\/744"}],"collection":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/invited_reviews"}],"about":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/types\/invited_reviews"}],"wp:attachment":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media?parent=744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}