{"id":443,"date":"2023-02-23T22:39:35","date_gmt":"2023-02-23T22:39:35","guid":{"rendered":"https:\/\/ladomerylab.org\/?page_id=443"},"modified":"2023-03-11T00:57:05","modified_gmt":"2023-03-11T00:57:05","slug":"research-papers","status":"publish","type":"page","link":"https:\/\/ladomerylab.org\/research-papers\/","title":{"rendered":"Research Papers"},"content":{"rendered":"

SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia<\/strong><\/a>
British Journal of Biomedical Science 80:1-10<\/i><\/strong> (2023)<\/p><\/div><\/div>

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer<\/strong><\/a>
Scientific Reports 11:7963<\/i><\/strong> (2021)<\/p><\/div><\/div>

APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps<\/strong><\/a>
Cancer Informatics 19: 1\u20138<\/i><\/strong> (2020)<\/p><\/div><\/div>

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1<\/strong><\/a>
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1863: 194642<\/i><\/strong> (2020)<\/p><\/div><\/div>

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer<\/strong><\/a>
Br J Cancer 123: 1024-1032<\/i><\/strong> (2020)<\/p><\/div><\/div>

Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii<\/strong><\/a>
Sci Rep 9: 12063<\/i><\/strong> (2019)<\/p><\/div><\/div>

Phenethyl isothiocyanate hampers growth and progression of HER2-positive cancer models by targeting their cancer stem cell compartment<\/strong><\/a>
Cellular Oncology (Dordr) 42: 815-828<\/i><\/strong> (2019)<\/p><\/div><\/div>

Altered VEGF splicing isoform balance in tumor endothelium involves activation of splicing factors Srpk1 and Srsf1 by the Wilms\u2019 tumor suppressor Wt1<\/strong><\/a>
Cells 8: E41.<\/i><\/strong> (2019)<\/p><\/div><\/div>

The evolutionarily conserved cassette exon 7b drives ERG’s oncogenic properties<\/strong><\/a>
Transl Oncol 12: 134-142.<\/i><\/strong> (2018)<\/p><\/div><\/div>

Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention<\/strong><\/a>
Gene 670: 46\u201354<\/i><\/strong> (2018)<\/p><\/div><\/div>

Hypoxia leads to significant alternative splicing changes and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells<\/strong><\/a>
BMC Cancer 18:355<\/i><\/strong> (2018)<\/p><\/div><\/div>

Residual ground-water levels of the neonicotinoid thiacloprid perturb chemo-sensing of Caenorhabditis elegans<\/strong><\/a>
Ecotoxicology 26, 981-990<\/i><\/strong> (2017)<\/p><\/div><\/div>

The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells<\/strong><\/a>
Oncology Letters 14, 5605-5610<\/i><\/strong> (2017)<\/p><\/div><\/div>

Insulin receptor isoform variations in prostate cancer cells<\/strong><\/a>
Front Endocrinol (Lausanne) 7:132<\/i><\/strong> (2016)<\/p><\/div><\/div>

The Scd6 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes<\/strong><\/a>
Biochim Biophys Acta 1849, 1363-1373<\/i><\/strong> (2015)<\/p><\/div><\/div>

SRPK1 inhibition and modulation of VEGF alternative splicing as a potential therapeutic strategy in prostate cancer<\/strong><\/a>
Oncogene 34, 4311-4319<\/i><\/strong> (2015)<\/p><\/div><\/div>

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, and hence angiogenesis, growth and resistance<\/strong><\/a>
Molecular Oncology 9, 167-178<\/i><\/strong> (2015)<\/p><\/div><\/div>

Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent<\/strong><\/a>
Anticancer Res 33, 4395-4400<\/i><\/strong> (2013)<\/p><\/div><\/div>

Quantitative analysis of ERG expression and its splice isoforms in formalin fixed paraffin embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence<\/strong><\/a>
Am J Clin Pathol 142, 533-540<\/i><\/strong> (2014)<\/p><\/div><\/div>

Modulation of the antioxidant\/pro-oxidant balance, cytotoxicity and antiviral actions of grape seed extracts<\/strong><\/a>
Food Chem. 141: 3967-3976<\/i><\/strong> (2013)<\/p><\/div><\/div>

A MMLV reverse transcriptase with reduced RNaseH activity allows greater sensitivity of gene expression detection in formalin fixed and paraffin embedded prostate cancer samples<\/strong><\/a>
Exp & Mol Pathol 95: 98-104<\/i><\/strong> (2013)<\/p><\/div><\/div>

Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells<\/strong><\/a>
Int J Oncol 43, 194-200<\/i><\/strong> (2013)<\/p><\/div><\/div>

WT1 mutants reveal SRPK1 to be a novel downstream angiogenesis target by altering VEGF splicing<\/strong><\/a>
Cancer Cell 20, 768-80<\/i><\/strong> (2011)<\/p><\/div><\/div>

Regulation of Vascular Endothelial Growth Factor Splicing from pro-angiogenic to anti-angiogenic isoforms – a novel therapeutic strategy for angiogenesis<\/strong><\/a>
J Biol Chem 285, 5532-5540<\/i><\/strong> (2010)<\/p><\/div><\/div>

Kinetic behaviour of WT1’s zinc-finger domain in binding to the alpha-actinin 1 mRNA<\/strong><\/a>
Arch Biochem Biophys 497, 21-27<\/i><\/strong> (2010)<\/p><\/div><\/div>

P19 H-Ras induces G1\/S phase delay maintaining cells in a reversible quiescence state<\/strong><\/a>
PLoS One 4, e8513<\/i><\/strong> (2009)<\/p><\/div><\/div>

A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8<\/strong><\/a>
Mol. Biol. Rep. 37, 839-845<\/i><\/strong> (2010)<\/p><\/div><\/div>

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors<\/strong><\/a>
J. Cell Sci. 121: 3487-3495<\/i><\/strong> (2008)<\/p><\/div><\/div>

A proteomic investigation of glomerular podocytes from a Denys-Drash syndrome patient with a mutation in the Wilms tumour suppressor gene WT1<\/strong><\/a>
Proteomics 7: 804-815<\/i><\/strong> (2007)<\/p><\/div><\/div>

Presence of WT1 in nuclear messenger RNP particles in the human acute myeloid leukemia cell lines HL60 and K562<\/strong><\/a>
Cancer Lett. 244: 136-141<\/i><\/strong> (2006)<\/p><\/div><\/div>

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo<\/strong><\/a>
Exp. Cell Res. 312: 3379-3388 (2006) - PMID: 16934801<\/i><\/strong> ()<\/p><\/div><\/div>

The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain<\/strong><\/a>
Biochem. Cell. Biol. 84: 789-798 (2006) - PMID: 17167543<\/i><\/strong> ()<\/p><\/div><\/div>

The Wilms’ tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron<\/strong><\/a>
Genes & Dev. 20: 1597-1608<\/i><\/strong> (2006)<\/p><\/div><\/div>

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation<\/strong><\/a>
Hum. Mol. Genet. 13: 235-246<\/i><\/strong> (2004)<\/p><\/div><\/div>

Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one<\/strong><\/a>
J. Cell Sci. 116: 1539-1549<\/i><\/strong> (2003)<\/p><\/div><\/div>

C4SR, a novel zinc-finger protein with SR-repeats, is expressed during early development of Xenopus<\/strong><\/a>
Gene 256: 293-302<\/i><\/strong> (2000)<\/p><\/div><\/div>

Presence of WT1, the Wilm’s tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein<\/strong><\/a>
J. Biol. Chem. 274: 36520-36526.<\/i><\/strong> (1999)<\/p><\/div><\/div>

Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes<\/strong><\/a>
Gene 198: 275-280<\/i><\/strong> (1997)<\/p><\/div><\/div>

Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes<\/strong><\/a>
Nucleic Acids Res. 25: 965-973<\/i><\/strong> (1997)<\/p><\/div><\/div>

Binding of Y-box proteins to RNA: involvement of different protein domains<\/strong><\/a>
Nucleic Acids Res. 22: 5582-5589.<\/i><\/strong> (1994)<\/p><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":605,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/443"}],"collection":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/comments?post=443"}],"version-history":[{"count":4,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/443\/revisions"}],"predecessor-version":[{"id":880,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/443\/revisions\/880"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media\/605"}],"wp:attachment":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media?parent=443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}