{"id":477,"date":"2023-02-23T23:13:41","date_gmt":"2023-02-23T23:13:41","guid":{"rendered":"https:\/\/ladomerylab.org\/?page_id=477"},"modified":"2023-03-09T11:47:05","modified_gmt":"2023-03-09T11:47:05","slug":"research-highlights","status":"publish","type":"page","link":"https:\/\/ladomerylab.org\/research-highlights\/","title":{"rendered":"Research Highlights"},"content":{"rendered":"

Hypoxia leads to significant alternative splicing changes and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells<\/strong><\/a>
BMC Cancer 18:355<\/i><\/strong> (2018)<\/p><\/div><\/div>

Residual ground-water levels of the neonicotinoid thiacloprid perturb chemo-sensing of Caenorhabditis elegans<\/strong><\/a>
Ecotoxicology 26, 981-990<\/i><\/strong> (2017)<\/p><\/div><\/div>

The Scd6 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes<\/strong><\/a>
Biochim Biophys Acta 1849, 1363-1373<\/i><\/strong> (2015)<\/p><\/div><\/div>

SRPK1 inhibition and modulation of VEGF alternative splicing as a potential therapeutic strategy in prostate cancer<\/strong><\/a>
Oncogene 34, 4311-4319<\/i><\/strong> (2015)<\/p><\/div><\/div>

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, and hence angiogenesis, growth and resistance<\/strong><\/a>
Molecular Oncology 9, 167-178<\/i><\/strong> (2015)<\/p><\/div><\/div>

WT1 mutants reveal SRPK1 to be a novel downstream angiogenesis target by altering VEGF splicing<\/strong><\/a>
Cancer Cell 20, 768-80<\/i><\/strong> (2011)<\/p><\/div><\/div>

Regulation of Vascular Endothelial Growth Factor Splicing from pro-angiogenic to anti-angiogenic isoforms – a novel therapeutic strategy for angiogenesis<\/strong><\/a>
J Biol Chem 285, 5532-5540<\/i><\/strong> (2010)<\/p><\/div><\/div>

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors<\/strong><\/a>
J. Cell Sci. 121: 3487-3495<\/i><\/strong> (2008)<\/p><\/div><\/div>

The Wilms’ tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron<\/strong><\/a>
Genes & Dev. 20: 1597-1608<\/i><\/strong> (2006)<\/p><\/div><\/div>

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation<\/strong><\/a>
Hum. Mol. Genet. 13: 235-246<\/i><\/strong> (2004)<\/p><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":605,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/477"}],"collection":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/comments?post=477"}],"version-history":[{"count":8,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/477\/revisions"}],"predecessor-version":[{"id":655,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/477\/revisions\/655"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media\/605"}],"wp:attachment":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media?parent=477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}