{"id":57,"date":"2023-02-21T11:47:04","date_gmt":"2023-02-21T11:47:04","guid":{"rendered":"https:\/\/ladomerylab.org\/?page_id=57"},"modified":"2023-03-15T16:49:42","modified_gmt":"2023-03-15T16:49:42","slug":"homepage","status":"publish","type":"page","link":"https:\/\/ladomerylab.org\/","title":{"rendered":"Homepage"},"content":{"rendered":"<figure id=\"attachment_603\" aria-describedby=\"caption-attachment-603\" style=\"width: 218px\" class=\"wp-caption alignright\"><a href=\"\/about\/molecular-biology-of-rna\/\"><img loading=\"lazy\" decoding=\"async\" class=\"body-image wp-image-603 size-medium\" src=\"https:\/\/ladomerylab.org\/wp-content\/uploads\/2023\/02\/molecular-bio-rna-e1678062017441-218x300.jpg\" alt=\"Book cover of Molecular Biology of RNA\" width=\"218\" height=\"300\" srcset=\"https:\/\/ladomerylab.org\/wp-content\/uploads\/2023\/02\/molecular-bio-rna-e1678062017441-218x300.jpg 218w, https:\/\/ladomerylab.org\/wp-content\/uploads\/2023\/02\/molecular-bio-rna-e1678062017441.jpg 536w\" sizes=\"(max-width: 218px) 100vw, 218px\" \/><\/a><figcaption id=\"caption-attachment-603\" class=\"wp-caption-text\">A systematic overview of the exciting and rapidly moving field of RNA biology. <a href=\"\/about\/molecular-biology-of-rna\/\">Learn More<\/a>.<\/figcaption><\/figure>\n<p>The focus of my research group is on alternative splicing. Alternative splicing is the main process through which genes can express multiple protein isoforms. ~94% of human protein-coding genes are alternatively spliced and it is estimated that ~15% of all disease-associated mutations in humans affect alternative splicing.<\/p>\n<h4>Current and recent projects<\/h4>\n<ul>\n<li>Involvement and targeting of the SR protein kinases SRPK1 and CLK1 in cancer<\/li>\n<li>Alternative splicing of VEGF, HER2, ERG, and the Insulin Receptor<\/li>\n<li>Cellular adaptation to hypoxia through regulated alternative splicing<\/li>\n<li>The role of ERG and its splice isoforms in prostate and other types of cancer<\/li>\n<li>Function of stress-induced Arabidopsis mRNA-binding proteins atGRP7\/8\/2<\/li>\n<li>Function of <em>Chlamydomonas reinhardtii<\/em> RNA-binding protein CrGRP1 in stress adaptation<\/li>\n<li>Textbook: The Molecular Biology of RNA. Elliott and Ladomery. First edition published in 2011, Oxford University Press. Second edition published in 2016. Primers version to be published in 2023.<\/li>\n<\/ul>\n<h4>Latest five papers<\/h4>\n<p>Click on the title to view the abstract.<\/p>\n<section id=\"brxe-clwpit\" class=\"brxe-section\"><div class=\"brxe-fkelqu brxe-container\"><div class=\"brxe-okzckz brxe-block\"><p class=\"brxe-aersvf brxe-text-basic\"><a href=\"https:\/\/ladomerylab.org\/research-papers\/sphinx-based-combination-therapy-as-a-potential-novel-treatment-strategy-for-acute-myeloid-leukaemia\/\"><strong>SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia<\/strong><\/a><br><strong><i>British Journal of Biomedical Science 80:1-10<\/i><\/strong> (2023)<\/p><\/div><\/div><div class=\"brxe-fkelqu brxe-container\"><div class=\"brxe-okzckz brxe-block\"><p class=\"brxe-aersvf brxe-text-basic\"><a href=\"https:\/\/ladomerylab.org\/research-papers\/cdc2-like-clk-protein-kinase-inhibition-as-a-novel-targeted-therapeutic-strategy-in-prostate-cancer\/\"><strong>CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer<\/strong><\/a><br><strong><i>Scientific Reports 11:7963<\/i><\/strong> (2021)<\/p><\/div><\/div><div class=\"brxe-fkelqu brxe-container\"><div class=\"brxe-okzckz brxe-block\"><p class=\"brxe-aersvf brxe-text-basic\"><a href=\"https:\/\/ladomerylab.org\/research-papers\/apc-and-axin2-are-promising-biomarker-candidates-for-the-early-detection-of-adenomas-and-hyperplastic-polyps\/\"><strong>APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps<\/strong><\/a><br><strong><i>Cancer Informatics 19: 1\u20138<\/i><\/strong> (2020)<\/p><\/div><\/div><div class=\"brxe-fkelqu brxe-container\"><div class=\"brxe-okzckz brxe-block\"><p class=\"brxe-aersvf brxe-text-basic\"><a href=\"https:\/\/ladomerylab.org\/research-papers\/wt1-activates-transcription-of-the-splice-factor-kinase-srpk1-gene-in-pc3-and-k562-cancer-cells-in-the-absence-of-corepressor-basp1\/\"><strong>WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1<\/strong><\/a><br><strong><i>Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1863: 194642<\/i><\/strong> (2020)<\/p><\/div><\/div><div class=\"brxe-fkelqu brxe-container\"><div class=\"brxe-okzckz brxe-block\"><p class=\"brxe-aersvf brxe-text-basic\"><a href=\"https:\/\/ladomerylab.org\/research-papers\/targeting-the-erg-oncogene-with-splice-switching-oligonucleotides-as-a-novel-therapeutic-strategy-in-prostate-cancer\/\"><strong>Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer<\/strong><\/a><br><strong><i>Br J Cancer 123: 1024-1032<\/i><\/strong> (2020)<\/p><\/div><\/div><\/section>\n<h4>Interested in a self-funded PhD, or in a industrial partnership PhD?<\/h4>\n<p>From time to time, depending on grants, PhD studentships are available in my lab. However we are also happy to consider a self-funded (or part self-funded) PhD studentship at any time. Read more about the self-funded PhD studentship.<\/p>\n<p>We also have a scheme available for companies interested in investing in research; the partnership PhD scheme, in which companies can part-fund a PhD, 50% of costs (with a current minimum of 30%).<\/p>\n<p>Please contact Michael.Ladomery@uwe.ac.uk if interested.<\/p>\n<p>External partner: We are delighted to be collaborating with\u00a0<a href=\"http:\/\/www.learning-deep-learning.com\">Learning Deep Learning<\/a>, see collaborator pages.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I am interested in RNA biology, a growing area of research that includes RNA processing; alternative splicing; mRNA export, translation and localisation; mRNA stability; RNA interference and regulatory noncoding RNAs including microRNAs and lncRNAs.<\/p>\n","protected":false},"author":2,"featured_media":605,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/57"}],"collection":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/comments?post=57"}],"version-history":[{"count":24,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/57\/revisions"}],"predecessor-version":[{"id":890,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/pages\/57\/revisions\/890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media\/605"}],"wp:attachment":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media?parent=57"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}