{"id":534,"date":"2020-01-03T02:24:58","date_gmt":"2020-01-03T02:24:58","guid":{"rendered":"https:\/\/ladomerylab.org\/?post_type=research_papers&#038;p=534"},"modified":"2023-03-04T11:08:33","modified_gmt":"2023-03-04T11:08:33","slug":"xenopus-hdm-a-maternally-expressed-histone-deacetylase-belongs-to-an-ancient-family-of-acetyl-metabolizing-enzymes","status":"publish","type":"research_papers","link":"https:\/\/ladomerylab.org\/research-papers\/xenopus-hdm-a-maternally-expressed-histone-deacetylase-belongs-to-an-ancient-family-of-acetyl-metabolizing-enzymes\/","title":{"rendered":"Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes"},"content":{"rendered":"<p>Modification of core histones can alter chromatin structure, facilitating the activation and repression of genes. A key example is the acetylation of N-terminal lysines of the core histones. Recently, the mammalian histone deacetylase HD1 was cloned from Jurkat T cells, and shown to be 60% identical to the yeast global gene regulator Rpd3 (Taunton et al., 1996). Here we report the cloning of HDm, a maternally expressed putative deposition histone deacetylase from Xenopus laevis. Comparison of the amino acid sequences of histone deacetylases from diverse eukaryotes shows high levels of identity within a putative enzyme core region. Further alignment with other types of protein: acetoin-utilizing enzymes from eubacteria; acetylpolyamine hydrolases from mycoplasma and cyanobacteria; and a protein of unknown function from an archaebacterium, reveals an apparently conserved core, and suggests that histone deacetylases belong to an ancient family of enzymes with related functions.<\/p>\n","protected":false},"template":"","display_control":[],"_links":{"self":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/research_papers\/534"}],"collection":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/research_papers"}],"about":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/types\/research_papers"}],"wp:attachment":[{"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/media?parent=534"}],"wp:term":[{"taxonomy":"display_control","embeddable":true,"href":"https:\/\/ladomerylab.org\/wp-json\/wp\/v2\/display_control?post=534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}