Hypoxia leads to significant alternative splicing changes and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
April 23, 2022Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim…Residual ground-water levels of the neonicotinoid thiacloprid perturb chemo-sensing of Caenorhabditis elegans
March 4, 2022This study investigated the neurological effects of residual ground-water levels of thiacloprid on the non-target organism Caenorhabditis elegans. Nematodes treated…The Scd6 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes
December 4, 2021Oocytes accumulate mRNAs in the form of maternal ribonucleoprotein (RNP) particles, the protein components of which determine the location and…SRPK1 inhibition and modulation of VEGF alternative splicing as a potential therapeutic strategy in prostate cancer
October 4, 2021Angiogenesis is required for tumour growth and is induced principally by VEGF-A . VEGF-A pre-mRNA is alternatively spliced at the…Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, and hence angiogenesis, growth and resistance
September 4, 2021Objective. The angiogenic capability of colorectal carcinomas (CRC) is determined by alternative splicing of VEGF-A pre-mRNA. The intracellular protein TIA-1…WT1 mutants reveal SRPK1 to be a novel downstream angiogenesis target by altering VEGF splicing
April 1, 2021Angiogenesis is regulated by the balance of proangiogenic VEGF and antiangiogenic VEGFb splice isoforms. Mutations in WT1, the Wilms’ tumor…Regulation of Vascular Endothelial Growth Factor Splicing from pro-angiogenic to anti-angiogenic isoforms – a novel therapeutic strategy for angiogenesis
March 1, 2021Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in…Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors
December 1, 2020Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis.…The Wilms’ tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron
August 1, 2020The Wilms’ tumour 1 (WT1) gene plays an important role in mammalian urogenital development, and dysregulation of this gene is…Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
July 1, 2020Wt1 is a tumour suppressor gene, mutation of which is a cause of Wilms’ tumour, a childhood renal nephroblastoma. Wt1…