I am interested in RNA biology, a growing area of research that includes RNA processing; alternative splicing; mRNA export, translation and localisation; mRNA stability; RNA interference and regulatory noncoding RNAs including microRNAs and lncRNAs.

Book cover of Molecular Biology of RNA
A systematic overview of the exciting and rapidly moving field of RNA biology. Learn More.

The focus of my research group is on alternative splicing. Alternative splicing is the main process through which genes can express multiple protein isoforms. ~94% of human protein-coding genes are alternatively spliced and it is estimated that ~15% of all disease-associated mutations in humans affect alternative splicing.

Current and recent projects

  • Involvement and targeting of the SR protein kinases SRPK1 and CLK1 in cancer
  • Alternative splicing of VEGF, HER2, ERG, and the Insulin Receptor
  • Cellular adaptation to hypoxia through regulated alternative splicing
  • The role of ERG and its splice isoforms in prostate and other types of cancer
  • Function of stress-induced Arabidopsis mRNA-binding proteins atGRP7/8/2
  • Function of Chlamydomonas reinhardtii RNA-binding protein CrGRP1 in stress adaptation
  • Textbook: The Molecular Biology of RNA. Elliott and Ladomery. First edition published in 2011, Oxford University Press. Second edition published in 2016. Primers version to be published in 2023.

Latest five papers

Click on the title to view the abstract.

Interested in a self-funded PhD, or in a industrial partnership PhD?

From time to time, depending on grants, PhD studentships are available in my lab. However we are also happy to consider a self-funded (or part self-funded) PhD studentship at any time. Read more about the self-funded PhD studentship.

We also have a scheme available for companies interested in investing in research; the partnership PhD scheme, in which companies can part-fund a PhD, 50% of costs (with a current minimum of 30%).

Please contact Michael.Ladomery@uwe.ac.uk if interested.

External partner: We are delighted to be collaborating with Learning Deep Learning, see collaborator pages.

Portrait photo of Professor Micheal Ladomery
Swrc
Alt text
Denys Drash Syndrome podocytes on the cover of the journal Proteomics.