Research Papers

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome
Translational Oncology 46: 102030 (2024)

Anticancer Effects of the Novel Pyrazolyl-Urea GeGe-3
Int. J. Mol. Sci. 2024, 25, 5380. (2024)

SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia
British Journal of Biomedical Science 80:1-10 (2023)

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
Scientific Reports 11:7963 (2021)

APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps
Cancer Informatics 19: 1–8 (2020)

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1863: 194642 (2020)

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer
Br J Cancer 123: 1024-1032 (2020)

Abscisic acid induced a negative geotropic response in dark-incubated Chlamydomonas reinhardtii
Sci Rep 9: 12063 (2019)

Phenethyl isothiocyanate hampers growth and progression of HER2-positive cancer models by targeting their cancer stem cell compartment
Cellular Oncology (Dordr) 42: 815-828 (2019)

Altered VEGF splicing isoform balance in tumor endothelium involves activation of splicing factors Srpk1 and Srsf1 by the Wilms’ tumor suppressor Wt1
Cells 8: E41. (2019)

The evolutionarily conserved cassette exon 7b drives ERG’s oncogenic properties
Transl Oncol 12: 134-142. (2018)

Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention
Gene 670: 46–54 (2018)

Hypoxia leads to significant alternative splicing changes and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
BMC Cancer 18:355 (2018)

Residual ground-water levels of the neonicotinoid thiacloprid perturb chemo-sensing of Caenorhabditis elegans
Ecotoxicology 26, 981-990 (2017)

The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells
Oncology Letters 14, 5605-5610 (2017)

Insulin receptor isoform variations in prostate cancer cells
Front Endocrinol (Lausanne) 7:132 (2016)

The Scd6 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes
Biochim Biophys Acta 1849, 1363-1373 (2015)

SRPK1 inhibition and modulation of VEGF alternative splicing as a potential therapeutic strategy in prostate cancer
Oncogene 34, 4311-4319 (2015)

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, and hence angiogenesis, growth and resistance
Molecular Oncology 9, 167-178 (2015)

Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent
Anticancer Res 33, 4395-4400 (2013)

Quantitative analysis of ERG expression and its splice isoforms in formalin fixed paraffin embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence
Am J Clin Pathol 142, 533-540 (2014)

Modulation of the antioxidant/pro-oxidant balance, cytotoxicity and antiviral actions of grape seed extracts
Food Chem. 141: 3967-3976 (2013)

A MMLV reverse transcriptase with reduced RNaseH activity allows greater sensitivity of gene expression detection in formalin fixed and paraffin embedded prostate cancer samples
Exp & Mol Pathol 95: 98-104 (2013)

Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells
Int J Oncol 43, 194-200 (2013)

WT1 mutants reveal SRPK1 to be a novel downstream angiogenesis target by altering VEGF splicing
Cancer Cell 20, 768-80 (2011)

Regulation of Vascular Endothelial Growth Factor Splicing from pro-angiogenic to anti-angiogenic isoforms – a novel therapeutic strategy for angiogenesis
J Biol Chem 285, 5532-5540 (2010)

Kinetic behaviour of WT1’s zinc-finger domain in binding to the alpha-actinin 1 mRNA
Arch Biochem Biophys 497, 21-27 (2010)

P19 H-Ras induces G1/S phase delay maintaining cells in a reversible quiescence state
PLoS One 4, e8513 (2009)

A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8
Mol. Biol. Rep. 37, 839-845 (2010)

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors
J. Cell Sci. 121: 3487-3495 (2008)

A proteomic investigation of glomerular podocytes from a Denys-Drash syndrome patient with a mutation in the Wilms tumour suppressor gene WT1
Proteomics 7: 804-815 (2007)

Presence of WT1 in nuclear messenger RNP particles in the human acute myeloid leukemia cell lines HL60 and K562
Cancer Lett. 244: 136-141 (2006)

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo
Exp. Cell Res. 312: 3379-3388 (2006) - PMID: 16934801 ()

The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain
Biochem. Cell. Biol. 84: 789-798 (2006) - PMID: 17167543 ()

The Wilms’ tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron
Genes & Dev. 20: 1597-1608 (2006)

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
Hum. Mol. Genet. 13: 235-246 (2004)

Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one
J. Cell Sci. 116: 1539-1549 (2003)

C4SR, a novel zinc-finger protein with SR-repeats, is expressed during early development of Xenopus
Gene 256: 293-302 (2000)

Presence of WT1, the Wilm’s tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein
J. Biol. Chem. 274: 36520-36526. (1999)

Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes
Gene 198: 275-280 (1997)

Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes
Nucleic Acids Res. 25: 965-973 (1997)

Binding of Y-box proteins to RNA: involvement of different protein domains
Nucleic Acids Res. 22: 5582-5589. (1994)